48. Sun, Z., T. Wu, F. Zhao, A. Lau, C. M. Birch, and D. D. Zhang. 2011. KPNA6 (Importin {alpha}7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response. Mol Cell Biol 31:1800-11. PMID: 21383067. [Pubmed][PDF]

47. Kong, S., S. J. Kim, B. Sandal, S. M. Lee, B. Gao, D. D. Zhang, and D. Fang. 2011. The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation. J Biol Chem 286:16967-75. PMID: 21454709. [Pubmed][PDF]

46. Ren, D., N. F. Villeneuve, T. Jiang, T. Wu, A. Lau, H. A. Toppin, and D.D. Zhang. 2011. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A 108(4):1433-1438. PMID: 21205897 [Pubmed][PDF]

45. Chen N, X. Yi, N. Abushahin, S. Pang, D.D. Zhang, B. Kong, W. Zheng. 2010. Nrf2 expression in endometrial serous carcinomas and its precancers. Int J Clin Exp Pathol. 4(1):85-96. PMID: 21228930 [Pubmed][PDF]

44. Chen, C. H., V. Gau, D. D. Zhang, J. C. Liao, F. Y. Wang, and P. K. Wong. 2010. Statistical metamodeling for revealing synergistic antimicrobial interactions. PLoS One 5:e15472. PMID: 21124958 [Pubmed][PDF]

43. Villeneuve, N. F., A. Lau, and D. D. Zhang. 2010. Regulation of the Nrf2-Keap1 Antioxidant response by the ubiquitin proteasome system: an insight into Cullin-Ring ubiquitin ligases. Antioxid Redox Signal 13(11):1699-1712 PMID: 20486766 [Pubmed][PDF]

42. D. D. Zhang. 2010. The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer. Antioxid Redox Signal. (in press). PMID: 20486759 [Pubmed][PDF]

41. Wondrak, G.T., N. F. Villeneuve, S.D. Lamore, A. S. Bause, T. Jiang, and D. D. Zhang. 2010. The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. Molecules 15(5):3338-55. PMID:20657484. [Pubmed][PDF]

40. Jiang, T., N. Chen, F. Zhao, X.J. Wang, B. Long, W. Zheng, and D. D. Zhang. 2010. High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res. [Pubmed][PDF]

39. Lau A., X.J. Wang, F. Zhao, N.F. Villeneuve, T. Wu, T. Jiang, Z. Sun, E. White, and D. D. Zhang. 2010. A non-canonical mechanism of nrf2 activation by autophagy deficiency: a direct interaction between Keap1 and p62. Mol Cell Biol (in press). PMID: 20421418 [Pubmed][PDF]

38. Hur, W., Z. Sun, T. Jiang, D. E. Mason, E. C. Peters, D. D. Zhang., H. Luesch, P. G. Schultz, and N. S. Gray. 2010. A Small-Molecule Inducer of the Antioxidant Response Element. Chem Biol. 17:537-547. [Pubmed][PDF]

37. Jiang T., Z. Huang, Y. Lin, Z. Zhang, D. Fang, and D. D. Zhang. 2010. The protective role of Nrf2 in STZ-induced diabetic nephropathy. Diabetes 59(4):850-60. PMID:20103708 [Pubmed][PDF]

36. Chen C.H., Y. Lu, M. L. Sin, K. E. Mach, and D. D. Zhang, V. Gau, J.C. Liao, and P.K. Wong. 2010. Antimicrobial Susceptibility Testing Using High Surface-to-Volume Ratio Microchannels. Analytical Chemistry 82(3):1012-9. [Pubmed][PDF]

35. Villeneuve, N. F., Z. Sun, W. Chen, and D. D. Zhang.. 2009. Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels. Cell Cycle [Pubmed][PDF]

34. Chen A., B. Gao, J. Zhang, S-M Lee, D. D. Zhang., and D. Fang. 2009. The HECT-type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T Cell Death by Catalyzing EGR2 ubiquitination. Mol Cell Biol (accepted) [Pubmed][PDF]

33. Sun, Z., Z. Huang, and D. D. Zhang.. 2009. Phosphorylation of Nrf2 at multiple sites by MAP kinases has limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS ONE 4:e6588.[Pubmed][PDF]

32. Chen, W., Z. Sun, X. J. Wang, T. Jiang, Z. Huang, D. Fang, and D. D. Zhang.. 2009. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell 34:663-73. [Pubmed][PDF] (This paper was featured by Michel B. Toledano in the same issue 637-639). [Pubmed][PDF]

31. Gideani, V., R. Riahi, D. D. Zhang., and P. K. Wong. 2009. Hybridization kinetics of double-stranded DNA probes for rapid molecular analysis. Analyst 134:1675-1681.[WEB][PDF]

30. Jiang, T., Z. Huang, J. Y. Chan, and D. D. Zhang.. 2009. Nrf2 protects against As(III)-induced damage in mouse liver and bladder. Toxicol Appl Pharmacol.[Pubmed][PDF]

29. Zhao, F., T. Wu, A. Lau, T. Jiang, Z. Huang, X. J. Wang, W. Chen, P. K. Wong, and D. D. Zhang.. 2009. Nrf2 promotes neuronal cell differentiation. Free Radic Biol Med.DOI: 10.1016 [Pubmed][PDF]

28. Wang, X. J., and D. D. Zhang. 2009. Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. PLoS One 4:e5492.doi:10.1371/journal.pone.0005492 [Pubmed][PDF]

27. Sun, Z., Y. E. Chin, andD. D. Zhang. 2009. Acetylation of Nrf2 by p300/CBP Augments Promoter-specific DNA Binding of Nrf2 during Antioxidant Response. Mol Cell Biol. (doi:10.1128/MCB.101639-08).[Pubmed][PDF]

26. Lau, A., N. F. Villeneuve, Z. Sun, P. K. Wong, andD. D. Zhang. 2008. Dual roles of Nrf2 in cancer. Pharmacol Res 58:262-70.[Pubmed][PDF]

25. Wang Z., V. Gidwani, D. D. Zhang, and P. K. Wong. 2008. Separation-free detection of nuclear factor kappa B with double-stranded molecular probes. The Analyst. (DOI: 10.1039/b809113g).[Pubmed][PDF]

24. Du Y., N. F. Villeneuve, X. J. Wang, Z. Sun, W. Chen, J. Li, H. Lou, P. K. Wong, and D. D. Zhang. 2008. Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Perspect. (doi:10.1289/ehp.11464 (available at http://dx.doi.org/).[WEB][PDF]

23. Wang Z., V. Gidwani, Z. Sun, D. D. Zhang, and P. K. Wong. 2008. Development of a molecular assay for rapid screening of chemopreventive compounds targeting Nrf2. Journal of the Association for Laboratory Automation 13: 243-8.[WEB][PDF]

22. Meserve. D., Z. Wang, D. D. Zhang, and P. K. Wong. 2008. A double stranded molecular probe for Nucleic Acid analysis. The Analyst. (DOI: 10.1039/b804853c).[Pubmed][PDF]

21. Wondrak, G. T., C. M. Cabello, N. F. Villeneuve, S. Zhang, S. Ley, Y. Li, Z. Sun, and D. D. Zhang. 2008. Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress. Free Radic Biol Med. (PMID: 18482591).[Pubmed][PDF]

20. Wang, X. J., Z. Sun, N. F. Villeneuve, S. Zhang, F. Zhao, Y. Li, W. Chen, X. Yi, W. Zheng, G. T. Wondrak, P. K. Wong, and D. D. Zhang. 2008. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis. (PMID: 18413364).[Pubmed][PDF]

19. Wang, X. J., Z. Sun, W. Chen, Y. Li, N. F. Villeneuve, and D. D. Zhang. 2008. Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. Toxicol Appl Pharmacol. (PMID: 18417180).[Pubmed][PDF]

18. Gao, B., S. M. Lee, A. Chen, J. Zhang, D. D. Zhang, K. Kannan, R. A. Ortmann, and D. Fang. 2008. Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep 9:480-5. [Pubmed][PDF]

17.Wang, X. J., Z. Sun, W. Chen, K. E. Eblin, J. A. Gandolfi, and D. D. Zhang. 2007. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol 225:206-13. [Pubmed] [PDF]

16.Sun, Z., S. Zhang, J. Y. Chan, and D. D. Zhang. 2007. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol Cell Biol 27:6334-49.[Pubmed] [PDF]

15. Zhang, D. D. 2006. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 38:769-89.[Pubmed] [PDF]

14.Zhang, D. D., S. C. Lo, Z. Sun, G. M. Habib, M. W. Lieberman, and M. Hannink. 2005. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem 280:30091-9. [Pubmed] [PDF]

13.Ansell, P. J., S. C. Lo, L. G. Newton, C. Espinosa-Nicholas, D. D. Zhang, J. H. Liu, M. Hannink, and D. B. Lubahn. 2005. Repression of cancer protective genes by 17beta-estradiol: Ligand-dependent interaction between human Nrf2 and estrogen receptor alpha. Mol Cell Endocrinol 243:27-34. [Pubmed] [PDF]

12.Li, X., D. D. Zhang, M. Hannink, and L. J. Beamer. 2004. Crystal structure of the Kelch domain of human Keap1. J Biol Chem 279:54750-8. [Pubmed] [PDF]

11.Zhang, D. D., S. C. Lo, J. V. Cross, D. J. Templeton, and M. Hannink. 2004. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24:10941-53. [Pubmed] [PDF]

10.Li, X., D. Zhang, M. Hannink, and L. J. Beamer. 2004. Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Acta Crystallogr D Biol Crystallogr 60:2346-8.[Pubmed] [PDF]

9.Zhang, D. D., and M. Hannink. 2003. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23:8137-51. [Pubmed] [PDF]

8., S. B., D. D. Zhang, M. Hannink, E. Arvisais, R. J. Kaufman, and J. A. Diehl. 2003. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23:7198-209.[Pubmed] [PDF]

7.Salnikow, K., T. Davidson, T. Kluz, H. Chen, D. Zhou, and M. Costa. 2003. GeneChip analysis of signaling pathways affected by nickel. J Environ Monit 5:206-9.[Pubmed] [PDF]

6.Zhang, D. D., M. A. Hartsky, and D. B. Warheit. 2002. Time course of quartz and TiO(2) particle-induced pulmonary inflammation and neutrophil apoptotic responses in rats. Exp Lung Res 28:641-70. [Pubmed] [PDF]

5., S., S. Bagchi, D. D. Zhang, A. C. Mings, and M. Hannink. 2000. Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway. Mol Cell Biol 20:1571-82. [Pubmed] [PDF]

4.Zhou D*., M. A. Hartsky, and D. B. Warheit. 1999. Differential Apoptotic Responses of Pulmonary Inflammatory Cells in Rats Following in vivo Exposures to Quartz or TiO2 Particles. ILSI proceedings. 

3.Salnikow K., D. Zhou*, T. Kluz, C. Wang, and M. Costa. 1999. A New Gene Induced by a Rise in Free Intracellular Ca2+ Following Ni 2+ Exposure. In Metals and Genetics. ed. Sarkar (Plenum, New York). 131-144.  

2.Zhou D., K. Salnikow, and M. Costa. 1998. Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res 58:2182-9. [Pubmed] [PDF]

1.Costa M., K. Salnikow, Y. Lee, and D. Zhou*. 1997. Molecular Biology of Nickel carcinogenesis. Journal of Inorganic Biochemistry. 67 (1-4): 372-372. [PDF]

*Zhou, D. is the former name of Zhang, Donna D.