73. Wu T, Wang XJ, Tian W, Jaramillo MC, Lau ,D.D. Zhang. 2013. Poly (ADP-ribose) polymerase-1 Modulates Nrf2-dependent Transcription. Free Radic Biol Med. (accepted). PMID: 24140708 [Pubmed]

72. Qiao S, Tao S, Rojo de la Vega M, Park SL, Vonderfecht AA,Jacobs SL,D.D. Zhang, Wondrak GT. 2013. The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death. Autophagy(accepted). PMID: 24113242 [Pubmed]

71. Jaramillo MC,D.D. Zhang. 2013. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev (accepted). PMID: 24142871[Pubmed][PDF]

70. Whitman SA, Long M, Wondrak GT, Zheng H,D.D. Zhang. 2013. Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy. Exp Cell Res (accepted). PMID: 23896025 [Pubmed][PDF]

69. Qiu Q, Zheng Z, Chang L, Zhao YS, Tan C, Dandekar A, Zhang Z, Lin Z, Gui M, Li X, Zhang T, Kong Q, Li H, Chen S, Chen A, Kaufman RJ, Yang WL, Lin HK,D.D. Zhang, Perlman H, Thorp E, Zhang K, Fang D. 2013. Toll-like receptor-mediated IRE1alpha activation as a therapeutic target for inflammatory arthritis. EMBO J. (accepted). PMID: 23942232 [Pubmed][PDF]

68. Chen W, Wang H, Tao S, Zheng Y, Wu W, Lian F, Jaramillo M, Fang D,D.D. Zhang. 2013. Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival. Cell Cycle (accepted). PMID: 23797580 [Pubmed][PDF]

67. Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D,D.D. Zhang. 2013. USP15 Negatively Regulates Nrf2 through Deubiquitination of Keap1. Mol Cell 51:68-79. PMID: 23727018 [Pubmed][PDF]

66. Ji L, Li H, Gao P, Shang G,D.D. Zhang, Zhang N, Jiang T. 2013. Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer. PLoS One 8:e63404.P MID: 23667609 [Pubmed][PDF]

65. Riahi R, Dean Z, Wu TH, Teitell MA, Chiou PY,D.D. Zhang, Wong PK. 2013. Detection of mRNA in living cells by double-stranded locked nucleic acid probes. Analyst. PMID: 23772441 [Pubmed][PDF]

64. Lau A, Zheng Y, Tao S, Wang H, Whitman SA, White E,D.D. Zhang. 2013. Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner. Mol Cell Biol 33:2436-2446. PMID: 23589329 [Pubmed][PDF]

63. Lu Y, Gao J,D.D. Zhang, Gau V, Liao JC, Wong PK. 2013. Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading. Anal Chem 85:3971-3976. PMID: 23445209. [Pubmed][PDF]

62. Wu W, Qiu Q, Wang H, Whitman SA, Fang D, Lian F,D.D. Zhang. 2013. Nrf2 is crucial to graft survival in a rodent model of heart transplantation. Oxidative medicine and cellular longevity 2013:919313. PMID: 23533698 [Pubmed][PDF]

61. Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, Wong PK, Wondrak GT,D.D. Zhang. 2013. Tanshinone I Activates the Nrf2-Dependent Antioxidant Response and Protects Against As(III)-Induced Lung Inflammation In Vitro and In Vivo. Antioxid Redox Signal. PMID: 23394605 [Pubmed][PDF]

60.D.D. Zhang. 2013. Bardoxolone Brings Nrf2-Based Therapies to Light. Antioxid Redox Signal. PMID: 23227819 [Pubmed][PDF]

59. Lau A, Whitman SA, Jaramillo MC,D.D. Zhang. 2013. Arsenic-mediated activation of the Nrf2-Keap1 antioxidant pathway. J Biochem Mol Toxicol 27:99-105. PMID: 23188707 [Pubmed][PDF]

58. Lau A, Tian W, Whitman SA,D.D. Zhang. 2013. The predicted molecular weight of nrf2: it is what it is not. Antioxid Redox Signal 18:91-93. PMID: 22703241 [Pubmed][PDF]

57. Zheng Y, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC,D.D. Zhang. 2012. Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. Toxicol Appl Pharmacol 265:292-299. PMID: 22975029 [Pubmed][PDF]

56. Wang F, Tian F, Whitman SA,D.D. Zhang, Nishinaka T, Zhang N, Jiang T. 2012. Regulation of transforming growth factor beta1-dependent aldose reductase expression by the Nrf2 signal pathway in human mesangial cells. European journal of cell biology 91:774-781. PMID: 22951256 [Pubmed][PDF]

55. Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS,D.D. Zhang, Rabinowitz JD, White E. 2012. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One 7:e41831. PMID: 22848625 [Pubmed][PDF]

54. Chen W, Jiang T, Wang H, Tao S, Lau A, Fang D,D.D. Zhang. 2012. Does Nrf2 contribute to p53-mediated control of cell survival and death? Antioxid Redox Signal 17:1670-1675. PMID: 22559194 [Pubmed][PDF]

53. Riahi R, Yang Y,D.D. Zhang, Wong PK. 2012. Advances in wound-healing assays for probing collective cell migration. Journal of laboratory automation 17:59-65. PMID: 22357609 [Pubmed][PDF]

52. Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, Mehta M, Cheung KL, Ganesan S, Kong AN,D.D. Zhang, Xia B. 2012. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol 32:1506-1517. PMID:22331464 [Pubmed][PDF]

51. Lin Z, Yang H, Kong Q, Li J, Lee SM, Gao B, Dong H, Wei J, Song J,D.D. Zhang, Fang D. 2012. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell 46:484-494. PMID:22542455 [Pubmed][PDF]

50. Hu Q,D.D. Zhang, Wang L, Lou H, Ren D. 2012. Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity. Food Chem Toxicol 50:1927-1932. PMID: 22465804 [Pubmed][PDF]

49. Zheng H, Whitman SA, Wu W, Wondrak GT, Wong PK, Fang D,D.D. Zhang. 2011. Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes 60:3055-3066. PMID:22025779. [Pubmed][PDF]

48. Sun, Z., T. Wu, F. Zhao, A. Lau, C. M. Birch, and D. D. Zhang. 2011. KPNA6 (Importin {alpha}7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response. Mol Cell Biol 31:1800-11. PMID: 21383067. [Pubmed][PDF]

47. Kong, S., S. J. Kim, B. Sandal, S. M. Lee, B. Gao, D. D. Zhang, and D. Fang. 2011. The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation. J Biol Chem 286:16967-75. PMID: 21454709. [Pubmed][PDF]

46. Ren, D., N. F. Villeneuve, T. Jiang, T. Wu, A. Lau, H. A. Toppin, and D.D. Zhang. 2011. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A 108(4):1433-1438. PMID: 21205897 [Pubmed][PDF]

45. Chen N, X. Yi, N. Abushahin, S. Pang, D.D. Zhang, B. Kong, W. Zheng. 2010. Nrf2 expression in endometrial serous carcinomas and its precancers. Int J Clin Exp Pathol. 4(1):85-96. PMID: 21228930 [Pubmed][PDF]

44. Chen, C. H., V. Gau, D. D. Zhang, J. C. Liao, F. Y. Wang, and P. K. Wong. 2010. Statistical metamodeling for revealing synergistic antimicrobial interactions. PLoS One 5:e15472. PMID: 21124958 [Pubmed][PDF]

43. Villeneuve, N. F., A. Lau, and D. D. Zhang. 2010. Regulation of the Nrf2-Keap1 Antioxidant response by the ubiquitin proteasome system: an insight into Cullin-Ring ubiquitin ligases. Antioxid Redox Signal 13(11):1699-1712 PMID: 20486766 [Pubmed][PDF]

42. D. D. Zhang. 2010. The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer. Antioxid Redox Signal. (in press). PMID: 20486759 [Pubmed][PDF]

41. Wondrak, G.T., N. F. Villeneuve, S.D. Lamore, A. S. Bause, T. Jiang, and D. D. Zhang. 2010. The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. Molecules 15(5):3338-55. PMID:20657484. [Pubmed][PDF]

40. Jiang, T., N. Chen, F. Zhao, X.J. Wang, B. Long, W. Zheng, and D. D. Zhang. 2010. High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res. [Pubmed][PDF]

39. Lau A., X.J. Wang, F. Zhao, N.F. Villeneuve, T. Wu, T. Jiang, Z. Sun, E. White, and D. D. Zhang. 2010. A non-canonical mechanism of nrf2 activation by autophagy deficiency: a direct interaction between Keap1 and p62. Mol Cell Biol (in press). PMID: 20421418 [Pubmed][PDF]

38. Hur, W., Z. Sun, T. Jiang, D. E. Mason, E. C. Peters, D. D. Zhang., H. Luesch, P. G. Schultz, and N. S. Gray. 2010. A Small-Molecule Inducer of the Antioxidant Response Element. Chem Biol. 17:537-547. [Pubmed][PDF]

37. Jiang T., Z. Huang, Y. Lin, Z. Zhang, D. Fang, and D. D. Zhang. 2010. The protective role of Nrf2 in STZ-induced diabetic nephropathy. Diabetes 59(4):850-60. PMID:20103708 [Pubmed][PDF]

36. Chen C.H., Y. Lu, M. L. Sin, K. E. Mach, and D. D. Zhang, V. Gau, J.C. Liao, and P.K. Wong. 2010. Antimicrobial Susceptibility Testing Using High Surface-to-Volume Ratio Microchannels. Analytical Chemistry 82(3):1012-9. [Pubmed][PDF]

35. Villeneuve, N. F., Z. Sun, W. Chen, and D. D. Zhang.. 2009. Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels. Cell Cycle [Pubmed][PDF]

34. Chen A., B. Gao, J. Zhang, S-M Lee, D. D. Zhang., and D. Fang. 2009. The HECT-type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T Cell Death by Catalyzing EGR2 ubiquitination. Mol Cell Biol (accepted) [Pubmed][PDF]

33. Sun, Z., Z. Huang, and D. D. Zhang.. 2009. Phosphorylation of Nrf2 at multiple sites by MAP kinases has limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS ONE 4:e6588.[Pubmed][PDF]

32. Chen, W., Z. Sun, X. J. Wang, T. Jiang, Z. Huang, D. Fang, and D. D. Zhang.. 2009. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell 34:663-73. [Pubmed][PDF] (This paper was featured by Michel B. Toledano in the same issue 637-639). [Pubmed][PDF]

31. Gideani, V., R. Riahi, D. D. Zhang., and P. K. Wong. 2009. Hybridization kinetics of double-stranded DNA probes for rapid molecular analysis. Analyst 134:1675-1681.[WEB][PDF]

30. Jiang, T., Z. Huang, J. Y. Chan, and D. D. Zhang.. 2009. Nrf2 protects against As(III)-induced damage in mouse liver and bladder. Toxicol Appl Pharmacol.[Pubmed][PDF]

29. Zhao, F., T. Wu, A. Lau, T. Jiang, Z. Huang, X. J. Wang, W. Chen, P. K. Wong, and D. D. Zhang.. 2009. Nrf2 promotes neuronal cell differentiation. Free Radic Biol Med.DOI: 10.1016 [Pubmed][PDF]

28. Wang, X. J., and D. D. Zhang. 2009. Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. PLoS One 4:e5492.doi:10.1371/journal.pone.0005492 [Pubmed][PDF]

27. Sun, Z., Y. E. Chin, andD. D. Zhang. 2009. Acetylation of Nrf2 by p300/CBP Augments Promoter-specific DNA Binding of Nrf2 during Antioxidant Response. Mol Cell Biol. (doi:10.1128/MCB.101639-08).[Pubmed][PDF]

26. Lau, A., N. F. Villeneuve, Z. Sun, P. K. Wong, andD. D. Zhang. 2008. Dual roles of Nrf2 in cancer. Pharmacol Res 58:262-70.[Pubmed][PDF]

25. Wang Z., V. Gidwani, D. D. Zhang, and P. K. Wong. 2008. Separation-free detection of nuclear factor kappa B with double-stranded molecular probes. The Analyst. (DOI: 10.1039/b809113g).[Pubmed][PDF]

24. Du Y., N. F. Villeneuve, X. J. Wang, Z. Sun, W. Chen, J. Li, H. Lou, P. K. Wong, and D. D. Zhang. 2008. Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Perspect. (doi:10.1289/ehp.11464 (available at http://dx.doi.org/).[WEB][PDF]

23. Wang Z., V. Gidwani, Z. Sun, D. D. Zhang, and P. K. Wong. 2008. Development of a molecular assay for rapid screening of chemopreventive compounds targeting Nrf2. Journal of the Association for Laboratory Automation 13: 243-8.[WEB][PDF]

22. Meserve. D., Z. Wang, D. D. Zhang, and P. K. Wong. 2008. A double stranded molecular probe for Nucleic Acid analysis. The Analyst. (DOI: 10.1039/b804853c).[Pubmed][PDF]

21. Wondrak, G. T., C. M. Cabello, N. F. Villeneuve, S. Zhang, S. Ley, Y. Li, Z. Sun, and D. D. Zhang. 2008. Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress. Free Radic Biol Med. (PMID: 18482591).[Pubmed][PDF]

20. Wang, X. J., Z. Sun, N. F. Villeneuve, S. Zhang, F. Zhao, Y. Li, W. Chen, X. Yi, W. Zheng, G. T. Wondrak, P. K. Wong, and D. D. Zhang. 2008. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis. (PMID: 18413364).[Pubmed][PDF]

19. Wang, X. J., Z. Sun, W. Chen, Y. Li, N. F. Villeneuve, and D. D. Zhang. 2008. Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. Toxicol Appl Pharmacol. (PMID: 18417180).[Pubmed][PDF]

18. Gao, B., S. M. Lee, A. Chen, J. Zhang, D. D. Zhang, K. Kannan, R. A. Ortmann, and D. Fang. 2008. Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep 9:480-5. [Pubmed][PDF]

17.Wang, X. J., Z. Sun, W. Chen, K. E. Eblin, J. A. Gandolfi, and D. D. Zhang. 2007. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol 225:206-13. [Pubmed] [PDF]

16.Sun, Z., S. Zhang, J. Y. Chan, and D. D. Zhang. 2007. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol Cell Biol 27:6334-49.[Pubmed] [PDF]

15. Zhang, D. D. 2006. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 38:769-89.[Pubmed] [PDF]

14.Zhang, D. D., S. C. Lo, Z. Sun, G. M. Habib, M. W. Lieberman, and M. Hannink. 2005. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem 280:30091-9. [Pubmed] [PDF]

13.Ansell, P. J., S. C. Lo, L. G. Newton, C. Espinosa-Nicholas, D. D. Zhang, J. H. Liu, M. Hannink, and D. B. Lubahn. 2005. Repression of cancer protective genes by 17beta-estradiol: Ligand-dependent interaction between human Nrf2 and estrogen receptor alpha. Mol Cell Endocrinol 243:27-34. [Pubmed] [PDF]

12.Li, X., D. D. Zhang, M. Hannink, and L. J. Beamer. 2004. Crystal structure of the Kelch domain of human Keap1. J Biol Chem 279:54750-8. [Pubmed] [PDF]

11.Zhang, D. D., S. C. Lo, J. V. Cross, D. J. Templeton, and M. Hannink. 2004. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24:10941-53. [Pubmed] [PDF]

10.Li, X., D. Zhang, M. Hannink, and L. J. Beamer. 2004. Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Acta Crystallogr D Biol Crystallogr 60:2346-8.[Pubmed] [PDF]

9.Zhang, D. D., and M. Hannink. 2003. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23:8137-51. [Pubmed] [PDF]

8., S. B., D. D. Zhang, M. Hannink, E. Arvisais, R. J. Kaufman, and J. A. Diehl. 2003. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23:7198-209.[Pubmed] [PDF]

7.Salnikow, K., T. Davidson, T. Kluz, H. Chen, D. Zhou, and M. Costa. 2003. GeneChip analysis of signaling pathways affected by nickel. J Environ Monit 5:206-9.[Pubmed] [PDF]

6.Zhang, D. D., M. A. Hartsky, and D. B. Warheit. 2002. Time course of quartz and TiO(2) particle-induced pulmonary inflammation and neutrophil apoptotic responses in rats. Exp Lung Res 28:641-70. [Pubmed] [PDF]

5., S., S. Bagchi, D. D. Zhang, A. C. Mings, and M. Hannink. 2000. Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway. Mol Cell Biol 20:1571-82. [Pubmed] [PDF]

4.Zhou D*., M. A. Hartsky, and D. B. Warheit. 1999. Differential Apoptotic Responses of Pulmonary Inflammatory Cells in Rats Following in vivo Exposures to Quartz or TiO2 Particles. ILSI proceedings

3.Salnikow K., D. Zhou*, T. Kluz, C. Wang, and M. Costa. 1999. A New Gene Induced by a Rise in Free Intracellular Ca2+ Following Ni 2+ Exposure. In Metals and Genetics. ed. Sarkar (Plenum, New York). 131-144.  

2.Zhou D., K. Salnikow, and M. Costa. 1998. Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res 58:2182-9. [Pubmed] [PDF]

1.Costa M., K. Salnikow, Y. Lee, and D. Zhou*. 1997. Molecular Biology of Nickel carcinogenesis. Journal of Inorganic Biochemistry. 67 (1-4): 372-372. [PDF]


*Zhou, D. is the former name of Zhang, Donna D.