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The research projects in Dr. Zhang’s laboratory are focused on (1) mechanistic studies of the Nrf2/Keap1 signaling pathway that regulate an antioxidant response, (2) the protective role of Nrf2 in arsenic-induced toxicity and carcinogenicity, (3) high-throughput screening of  chemopreventive compounds targeting Nrf2, and (4) regulation of gene expression by the ubiquitination and proteasomal degradation pathway.


   
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