Flynn AN, Tillu DT, Asiedu MN, Hoffman J, Vagner J, Price TJ, Boitano S. (2011) The protease-activated receptor-2 specific agonists, 2-aminothiazol-4-yl-LIGRL and 6-aminonicotinyl-LIGRL stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo. Journal of Biological Chemistry. In press. Asiedu MN, Tillu DV, Melemedjian OK, Shy A, Bodell B, Sanoja R, Ghosh S, Porreca F, Price TJ. (2011) Spinal PKM underlies the maintenance mechanism of persistent nociceptive sensitization. Journal of Neuroscience. 31(18) 6646-53. Boitano S, Flynn AN, Schulz SM, Hoffman J, Price TJ, Vagner J. (2011) Potent agonists of the Protease Activated Receptor 2 (PAR2). Journal of Medicinal Chemistry. 10; 54(5) 1308-13. Melemedjian OK, Asiedu MN, Tillu DV, Peebles K, Yan J, Ertz N, Dussor G, Price TJ. (2010) IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. Journal of Neuroscience. 30(45) 15113-23. Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. (2010) Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 151(2) 257-265. Asiedu M, Ossipov MH, Kaila K Price TJ. (2010) Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. Pain. 148 302-308. Sanoja R, Tortorici V, Fernandez C, Price TJ, Cervero F. (2010) Role of RVM neurons in capsaicin-evoked visceral nociception and referred hyperalgesia. European Journal of Pain. 14(2) 1-9. Price TJ, Geranton SM. (2009) Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology. European Journal of Neuroscience. 29(12) 2253-2263. Walczak JS, Price TJ, Cervero F. (2009) Cannabinoid CB1 receptors are expressed in the mouse urinary bladder and their activation modulates afferent bladder activity. Neuroscience. 159(3) 1154-63. Price TJ, Cervero F, Gold MS, Hammond DL, Prescott SA. (2009) Chloride regulation in the pain pathway. Brain Research Reviews. 60(1) 149-70. Price TJ, Rashid M, Millecamps M, Sanoja R, Entrena JM, Cervero F. (2007) Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR. Journal of Neuroscience. 27(51) 13958-13967 Pitcher MH, Price TJ, Entrena JM, Cervero F. (2007) Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia. Molecular Pain. 3(17). Price TJ, Flores CM (2006) Critical evaluation of colocalization of putative nociceptive markers in primary sensory ganglia: differences between the dorsal root (DRG) and trigeminal (TG) ganglia. Journal of Pain. 8(3) 263-72. Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM. (2006) Cannabinoid WIN 55,212-2 regulated TRPV1 phosphorylation in sensory neurons. Journal of Biological Chemistry. 281(43) 32879-32890. Price TJ, Hargreaves KM, Cervero F (2006) Protein expression and mRNA cellular distribution of the NKCC1 cotransporter in the dorsal root and trigeminal ganglia of the rat. Brain Research. 1112(1) 146-158. Patwardhan AM, Jeske NA, Price TJ, Akopian AN, Hargreaves KM (2006) The cannabinoid WIN 55,212 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proceedings of the National Academy of Sciences (USA). 103(30) 11393-8. Price TJ, Flores CM, Cervero F, Hargreaves KM (2006). The RNA binding and transport proteins staufen and fragile x mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons. Neuroscience. 141(4) 2107-2116. Price TJ, Jeske NA, Flores CM, Hargreaves KM (2005) Pharmacological interactions between calcium/calmodulin-dependent kinase II and TRPV1 receptors in rat trigeminal sensory neurons. Neuroscience Letters. 389(2) 94-8. Price TJ, Cervero F, DeKonick Y (2005) Role of cation-chloride cotransporters in pain and hyperalgesia. Current Topics in Medicinal Chemistry. 5(6) 547-555. Price TJ, Patwardhan AM, Flores CM, Hargreaves KM (2005). A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal nociceptors. Neuropharmacology 49(1) 25-39. Price TJ, Louria MD, Candelario-Soto D, Dussor GO, Jeske NA, Patwardhan AM, Diogenes A, Trott A, Hargreaves KM, Flores CM. (2005) Treatment of trigeminal ganglion neurons in vitro with NGF, GDNF and BDNF: effects on neuronal survival, neurochemical properties and TRPV1-mediated neuropeptide secretion. BMC Neuroscience 6(1): 4. Price TJ, Patwardhan A, Akopian A, Hargreaves KM, Flores CM. (2004) Cannabinoid receptor-independent actions of the aminoalkylindole cannabinoid WIN 55,212-2 on trigeminal sensory neurons. British Journal of Pharmacology. 142 (2) 257-66. Price TJ, Patwardhan A, Akopian A, Hargreaves KM, Flores CM. (2004) Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide (AEA), N-arachidonoyl-dopamine (NADA) and arachidonyl-2-chloroethylamide (ACEA). British Journal of Pharmacology 141(7) 1118-30. Price TJ, Dussor GO, Flores CM. (2003) Activating transcription factor 3 (ATF3) mRNA is up-regulated in primary cultures of trigeminal ganglion neurons. Molecular Brain Research, 118(1-2) 156-9. Dussor GO, Leong AS, Gracia NB, Kilo S, Price TJ, Hargreaves KM, Flores CM. (2003) Potentiation of Evoked CGRP Release from Oral Mucosa: A Potential Basis for the Pro-Inflammatory Effects of Nicotine. European Journal of Neuroscience, 18(9) 2515-26. Price TJ, Helesic G, Parghi D, Hargreaves KM, Flores CM. (2003) Cannabinoid receptor type one (CB1) expression and distribution in the trigeminal ganglion of the rat. Neuroscience, 120(1): 155-62. O'Toole AJ, Price TJ, Vetter T, Bartlett JC, Blanz V. (1999) 3D shape and 2D surface textures of human faces: the role of "averages" in attractiveness and age. Image And Vision Computing, 18 (1): 9-19. Price TJ, O'Toole AJ, Dambach KC. (1998) A moving cast shadow diminishes the Pulfrich phenomenon. Perception, 27(5): 591-3.

UA Home | College of Medicine | Pharmacology

B.S. Neuroscience (1997)

The University of Texas at Dallas

Mentor: Alice J O’Toole, PhD

Ph.D. Pharmacology (2003)

The University of Texas Health Science Center at San Antonio

Mentor: Christopher M. Flores, PhD

Postdoc Pain Neuroscience (2003-2004)

The University of Texas Health Science Center at San Antonio

Mentor: Kenneth M Hargreaves, DDS, PhD

Postdoc Pain Neuroscience (2004-2007)

McGill University

Mentor: Fernando Cervero, MD, PhD, DSc

Society for Neuroscience

American Pain Society

International Association for the Study of Pain

Flynn AN, Tillu DT, Asiedu MN, Hoffman J, Vagner J, Price TJ, Boitano S. (2011) The protease-activated receptor-2 specific agonists, 2-aminothiazol-4-yl-LIGRL and 6-aminonicotinyl-LIGRL stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo. Journal of Biological Chemistry. In press.

Asiedu MN, Tillu DV, Melemedjian OK, Shy A, Bodell B, Sanoja R, Ghosh S, Porreca F, Price TJ. (2011) Spinal PKM underlies the maintenance mechanism of persistent nociceptive sensitization. Journal of Neuroscience. 31(18) 6646-53.

Boitano S, Flynn AN, Schulz SM, Hoffman J, Price TJ, Vagner J. (2011) Potent agonists of the Protease Activated Receptor 2 (PAR2). Journal of Medicinal Chemistry. 10; 54(5) 1308-13.

Melemedjian OK, Asiedu MN, Tillu DV, Peebles K, Yan J, Ertz N, Dussor G, Price TJ. (2010) IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. Journal of Neuroscience. 30(45) 15113-23.

Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. (2010) Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 151(2) 257-265.

Asiedu M, Ossipov MH, Kaila K Price TJ. (2010) Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. Pain. 148 302-308.

Sanoja R, Tortorici V, Fernandez C, Price TJ, Cervero F. (2010) Role of RVM neurons in capsaicin-evoked visceral nociception and referred hyperalgesia. European Journal of Pain. 14(2) 1-9.

Price TJ, Geranton SM. (2009) Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology. European Journal of Neuroscience. 29(12) 2253-2263.

Walczak JS, Price TJ, Cervero F. (2009) Cannabinoid CB1 receptors are expressed in the mouse urinary bladder and their activation modulates afferent bladder activity. Neuroscience. 159(3) 1154-63.

Price TJ, Cervero F, Gold MS, Hammond DL, Prescott SA. (2009) Chloride regulation in the pain pathway. Brain Research Reviews. 60(1) 149-70.

Price TJ, Rashid M, Millecamps M, Sanoja R, Entrena JM, Cervero F. (2007) Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR. Journal of Neuroscience. 27(51) 13958-13967

Pitcher MH, Price TJ, Entrena JM, Cervero F. (2007) Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia. Molecular Pain. 3(17).

Price TJ, Flores CM (2006) Critical evaluation of colocalization of putative nociceptive markers in primary sensory ganglia: differences between the dorsal root (DRG) and trigeminal (TG) ganglia. Journal of Pain. 8(3) 263-72.

Jeske NA, Patwardhan AM, Gamper N, Price TJ, Akopian AN, Hargreaves KM. (2006) Cannabinoid WIN 55,212-2 regulated TRPV1 phosphorylation in sensory neurons. Journal of Biological Chemistry. 281(43) 32879-32890.

Price TJ, Hargreaves KM, Cervero F (2006) Protein expression and mRNA cellular distribution of the NKCC1 cotransporter in the dorsal root and trigeminal ganglia of the rat. Brain Research. 1112(1) 146-158.

Patwardhan AM, Jeske NA, Price TJ, Akopian AN, Hargreaves KM (2006) The cannabinoid WIN 55,212 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proceedings of the National Academy of Sciences (USA). 103(30) 11393-8.

Price TJ, Flores CM, Cervero F, Hargreaves KM (2006). The RNA binding and transport proteins staufen and fragile x mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons. Neuroscience. 141(4) 2107-2116.

Price TJ, Jeske NA, Flores CM, Hargreaves KM (2005) Pharmacological interactions between calcium/calmodulin-dependent kinase II and TRPV1 receptors in rat trigeminal sensory neurons. Neuroscience Letters. 389(2) 94-8.

Price TJ, Cervero F, DeKonick Y (2005) Role of cation-chloride cotransporters in pain and hyperalgesia. Current Topics in Medicinal Chemistry. 5(6) 547-555.

Price TJ, Patwardhan AM, Flores CM, Hargreaves KM (2005). A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal nociceptors. Neuropharmacology 49(1) 25-39.

Price TJ, Louria MD, Candelario-Soto D, Dussor GO, Jeske NA, Patwardhan AM, Diogenes A, Trott A, Hargreaves KM, Flores CM. (2005) Treatment of trigeminal ganglion neurons in vitro with NGF, GDNF and BDNF: effects on neuronal survival, neurochemical properties and TRPV1-mediated neuropeptide secretion. BMC Neuroscience 6(1): 4.

Price TJ, Patwardhan A, Akopian A, Hargreaves KM, Flores CM. (2004) Cannabinoid receptor-independent actions of the aminoalkylindole cannabinoid WIN 55,212-2 on trigeminal sensory neurons. British Journal of Pharmacology. 142 (2) 257-66.

Price TJ, Patwardhan A, Akopian A, Hargreaves KM, Flores CM. (2004) Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide (AEA), N-arachidonoyl-dopamine (NADA) and arachidonyl-2-chloroethylamide (ACEA). British Journal of Pharmacology 141(7) 1118-30.

Price TJ, Dussor GO, Flores CM. (2003) Activating transcription factor 3 (ATF3) mRNA is up-regulated in primary cultures of trigeminal ganglion neurons. Molecular Brain Research, 118(1-2) 156-9.

Dussor GO, Leong AS, Gracia NB, Kilo S, Price TJ, Hargreaves KM, Flores CM. (2003) Potentiation of Evoked CGRP Release from Oral Mucosa: A Potential Basis for the Pro-Inflammatory Effects of Nicotine. European Journal of Neuroscience, 18(9) 2515-26.

Price TJ, Helesic G, Parghi D, Hargreaves KM, Flores CM. (2003) Cannabinoid receptor type one (CB1) expression and distribution in the trigeminal ganglion of the rat. Neuroscience, 120(1): 155-62.

O'Toole AJ, Price TJ, Vetter T, Bartlett JC, Blanz V. (1999) 3D shape and 2D surface textures of human faces: the role of "averages" in attractiveness and age. Image And Vision Computing, 18 (1): 9-19.

Price TJ, O'Toole AJ, Dambach KC. (1998) A moving cast shadow diminishes the Pulfrich phenomenon. Perception, 27(5): 591-3.