PUBLICATIONS

(* corresponding author, # equal contribution)

  1. Ooi A*. Advances in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) research. Semin Cancer Biol. 2020 Apr;61:158-166.
  2. P Liu#, MJ Kerins#, W Tian, D Neupane, DD Zhang*, A Ooi*. Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells. Journal of Biological Chemistry 294 (48), 18131-18149
  3. MJ Kerins#, P Liu#, W Tian, W Mannheim, D Zhang*, A Ooi*.Genome wide CRISPR screen reveals autophagy disruption as the convergence mechanism that regulates the NRF2 transcription factor.Mol Cell Biol. 2019 Apr 22. pii: MCB.00037-19. doi: 10.1128/MCB.00037-19.
  4. Liu P, Vega MRDL, Sammani S, Mascarenhas JB, Kerins MJ, Dodson M, Sun X, Wang T, Ooi A, Garcia JGN, Zhang DD. RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE–dependent repression. PNAS October 30, 2018 115 (44) E10352-E10361.
  5. Kerins MJ, Ooi A*. A catalogue of somatic NRF2 gain-of-function mutations in cancer. Scientific reports 2018 Aug 27;8(1):12846.PubMed PMID: 30150714.
  6. Kerins MJ, Milligan J, Wohlschlegel JA, Ooi A*. Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction. Cancer Sci. 2018 Sep;109(9):2757-2766. PubMed PMID: 29917289.
  7. Tao S, Rojo de la Vega M, Chapman E, Ooi A, Zhang DD*. The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer. Mol Carcinog. 2018 Feb;57(2):182-192. doi: 10.1002/mc.22745. Epub 2017 Nov 6. PubMed PMID: 28976703; PubMed Central PMCID: PMC5760364.
  8. Tian W, Rojo de la Vega M, Schmidlin CJ, Ooi A, Zhang DD*. Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2). J Biol Chem. 2018 Feb 9;293(6):2029-2040. doi: 10.1074/jbc.RA117.000428. Epub 2017 Dec 18. PubMed PMID: 29255090; PubMed Central PMCID: PMC5808764.
  9. Kerins MJ, Ooi A*. The Roles of NRF2 in Modulating Cellular Iron Homeostasis. Antioxid Redox Signal. 2017 Sep 21. doi: 10.1089/ars.2017.7176. [Epub ahead of print] PubMed PMID: 28793787.
  10. Kerins MJ, Vashisht A, Liang BX, Duckworth SJ, Praslicka BJ, Wohlschlegel JA, Ooi A*. Fumarate mediates a chronic proliferative signal in fumarate hydratase inactivated cancer cells by increasing transcription and translation of ferritin genes. Mol Cell Biol. 2017 May 16;37(11). pii: e00079-17. PubMed PMID: 28289076; PubMed Central PMCID: PMC5440649.
  11. Praslicka B, Harmson JS, Kim J, Rangaraj VR, Ooi A, Gissendanner CR*. BINDING SITE ANALYSIS OF THE CAENORHABDITIS ELEGANS NR4A NUCLEAR RECEPTOR NHR-6 DURING DEVELOPMENT. Nucl Receptor Res. 2017;4. pii: 101288. doi: 10.11131/2017/101288. Epub 2017 Jul 23. PubMed PMID: 29026837; PubMed Central PMCID: PMC5634515.
  12. Harder B, Tian W, La Clair JJ, Tan AC, Ooi A , Chapman E, Zhang DD*. Brusatol overcomes chemoresistance through inhibition of protein translation. Mol Carcinog. 2017. 56:1493–1500. PubMed PMID: 28019675
  13. Knatko EV#, Praslicka B#, Higgins M, Evans A, Purdie KJ, Harwood CA, Proby CM, Ooi A*, Dinkova-Kostova AT*. Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. Cancer Prev Res (Phila). 2017 Jan;10(1):67-75.
  14. Brandon John Praslicka, Michael John Kerins, Aikseng Ooi*.The complex role of NRF2 in cancer: A genomic view. Current Opinion in Toxicology. 2016. 1:37-45
  15. Perrier-Trudova V, Huimin BW, Kongpetch S, Huang D, Ong P, Le Formal A, Poon SL, Siew EY, Myint SS, Gad S, Gardie B, Couvé S, Foong YM, Choudhury Y, Poh J, Ong CK, Toh CK, Ooi A, Richard S, Tan MH, Teh BT*. Fumarate Hydratase-deficient Cell Line NCCFH1 as a New In Vitro Model of Hereditary Papillary Renal Cell Carcinoma Type 2. Anticancer Res. 2015 Dec;35(12):6639-53. PubMed PMID: 26637880.
  16. Sandhu IS, Maksim NJ, Amouzougan EA, Gallion BW, Raviele AL, Ooi A*. Sustained NRF2 activation in hereditary leiomyomatosis and renal cell cancer (HLRCC) and in hereditary tyrosinemia type 1 (HT1). Biochem Soc Trans. 2015 Aug;43(4):650-6. PubMed PMID:26551707.
  17. Cutcutache I, Suzuki Y, Tan IB, Ramgopal S, Zhang S, Ramnarayanan K, Gan A, Lee HH, Tay ST, Ooi A, Ong CK, Bolthouse JT, Lane BR, Anema JG, Kahnoski RJ, Tan P*, Teh BT*, Rozen SG*. Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas. Eur Urol. 2015 Jan 14. pii: S0302-2838(14)01396-7. PubMed PMID: 25597018.
  18. Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD*. Oncogenic KRAS confers chemoresistance by upregulating NRF2. Cancer Res. 2014 Dec 15;74(24):7430-41. PubMed PMID: 25339352; PubMed Central PMCID: PMC4268230.
  19. Wong MH, Tan CS, Lee SC, Yong Y, Ooi AS, Ngeow J, Tan MH*. Potential genetic anticipation in hereditary leiomyomatosis-renal cell cancer (HLRCC). Fam Cancer. 2014 Jun;13(2):281-9. PubMed PMID:24526232.
  20. Ooi A*, Dykema K, Ansari A, Petillo D, Snider J, Kahnoski R, Anema J, Craig D, Carpten J, Teh BT, Furge KA*. CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic papillary renal cell carcinoma. Cancer Research. 2013. Apr 1; 73(7):2044-51. Pubmed PMID: 23365135
  21. Lee SY*, Qian CN, Ooi AS, Chen P, Wong BH, Myint SS, Wong JC, Hwang JS, Khee Chee S. Changes in specialized blood vessels in lymph nodes and their role in cancer metastasis. J Transl Med. 2012 Oct 4;10(1):206. PubMed PMID: 23035663.
  22. Ooi A, and Furge KA*. Fumarate Hydratase Inactivation in Renal Tumors: HIF1A Activation, NRF2 Activation and Cryptic Targets of Transcription Factors. Chin J Cancer. Chin J. Cancer. 2012 Sep; 31(9):413-20. Pubmed PMID: 22776233.
  23. Wondergem B, Zhang Z, Huang D, Ong CK, Koeman J, Hof DV, Petillo D, Ooi A, Anema J, Lane B, Kahnoski RJ, Furge KA, Teh BT*. Expression of the PTTG1 Oncogene Is Associated with Aggressive Clear Cell Renal Cell Carcinoma. Cancer Research. 2012 Sep 1;72(17):4361-71. PubMed PMID: 22805307.
  24. Ong CK, Subimerb C, Pairojkul C, Wongkham S, Cutcutache I, Yu W, McPherson JR, Allen GE, Ng CC, Wong BH, Myint SS, Rajasegaran V, Heng HL, Gan A, Zang ZJ, Wu Y, Wu J, Lee MH, Huang D, Ong P, Chan-On W, Cao Y, Qian CN, Lim KH, Ooi A, Dykema K, Furge K, Kukongviriyapan V, Sripa B, Wongkham C, Yongvanit P, Futreal PA, Bhudhisawasdi V*, Rozen S*, Tan P*, Teh BT*. Exome sequencing of liver fluke-associated cholangiocarcinoma. Nature Genetics. 2012 May 6;44(6):690-3. PubMed PMID: 22561520.
  25. Chong LY, Cheok PY, Tan WJ, Thike AA, Allen G, Ang MK, Ooi AS, Tan P, Teh BT*, Tan PH*. Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: novel markers in biological classification. Breast Cancer Res Treat. 2012 Feb; 132(1):143-51. PMID: 21574054
  26. Lee SY*, Qian CN, Ooi AS, Chen P, Tan VK, Chia CS, Hwang JS, Teh BT, Soo KC. 2011 Young Surgeon's Award Winner: High Endothelial Venules: A Novel Prognostic Marker in Cancer Metastasis and the Missing Link? Ann Acad Med Singapore. 2012 Jan; 41(1):21-8. PubMed PMID: 22499477.
  27. Ooi A, Wong JC, Petillo D, Roossien D, Perrier-Trudova V, Whitten D, Min BW, Tan MH, Zhang Z, Yang XJ, Zhou M, Gardie B, Molinié V, Richard S, Tan PH, Teh BT*, Furge KA*. An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma. Cancer Cell. 2011 Oct 18;20(4):511-23. PubMed PMID: 22014576
      This article was highlighted in:
    • Kinch L, Grishin NV, Brugarolas J. Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2. Cancer Cell. 2011 Oct 18;20(4):418-20. PubMed PMID: 22014567.
    • Nicola McCarthy. Kidney tumours: 'NRF said. Nature Reviews Cancer. 2011 Nov10;11(12):833. Pubmed PMID: 22071979.
    • Adam J, Ratcliffe PJ, Pollard PJ. Novel Insights into FH-associated Disease are KEAPing the Lid on Oncogenic HIF Signalling. Oncotarget. 2011 Nov; 2(11):820-1. PubMed PMID: 22064867.
    • Donner A. KEAPing NRF in check. Nature Chemical Biology. 2012 December; 8(1):21.
  28. Ang MK, Ooi AS, Thike AA, Tan P, Zhang Z, Dykema K, Furge K, Teh BT*, Tan PH*. Molecular classification of breast phyllodes tumors – validation of the histologic grading scheme and insights into malignant progression. Breast Cancer Res Treat. 2011 Sep;129(2):319-29. PMID: 20945089
  29. Li X-J, Ong CK, Cao Y, Xiang Y, Shao J-Y, Ooi A, Peng L-X, Lu W-H, Zhang Z, Petillo D, Qin L, Bao Y-N, Zheng F-J, Chia CS, Iyer NG, Kang T-B, Zeng Y-X, Soo KC, Trent JM, Teh BT*, Qian C-N*. Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. Cancer Research. 2011 Apr 15;71(8):3162-72. PMID: 21289131.
  30. Tan S-Y*, Ooi A-S, Ang M-K, Koh M, Wong J-C, Dykema K, Joanne N, Loong S, Gatter K, Tan L, Lim L-C, Furge K, Tao M, Lim S-T, Loong F, Cheah PL, Teh BT. Nuclear expression of MATK is a novel marker of Type II Enteropathy Associated T cell lymphoma. Leukemia. 2011 Mar;25(3): 555–557. PMID: 21233830
  31. Tan FL#, Ooi A#, Huang D*, Wong JC, Qian CN, Chao C, Ooi L, Tan YM, Chung A, Cheow PC, Zhang Z, Petillo D, Yang XJ, Teh BT. p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion. Int J Cancer. 2010 May 15;126(10): 2353–2361. PMID: 19816939
  32. Tan MH*, Yang J, Tan HL, Wong CF, Tan PH, Sim HG, Ang P, Toh CK, Tay MH, Poon E, Ooi AS, Teh BT. A unique pair of monozygotic twins with concordant clear cell renal cell carcinoma: a case report. Ann Acad Med Singapore. 2010 Jan;39(1): 61–3. PMID: 20126818
  33. Teoh PG, Ooi AS, AbuBakar S, Othman RY*. Virus-specific read-through codon preference affects infectivity of chimeric cucumber green mottle mosaic viruses displaying a dengue virus epitope. J Biomed Biotechnol. 2009;2009:781712 Epub 2009 Mar 22. PMID: 19325913
  34. Ooi A, Tan S, Mohamed R, Rahman NA, Othman RY*. The full-length clone of cucumber green mottle mosaic virus and its application as an expression system for Hepatitis B surface antigen. J Biotechnol. 2006 Feb 24;121(4): 471-81. PMID: 16271415