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Research Summary
My cCurrent research interests are focused on the development of biomedical imaging contrast agents.
I am developing enzyme responsive PARACEST-MR imaging contrast agents for the detection of protease activity related with angiogenesis
and apoptosis in cancer. I am interested in imaging contrast agents for MR/PET and MR/Photoacoustic dual-modal imaging
to maximize the efficiency in the detection of early stage cancer. An "Activatable" or "responsive" contrast agent is the basic concept
in my research. To carry out these research projects, I have been trained at CCIR (Case Center for Imaging Research) and
MIPS (Molecular Imaging Program at Stanford).
Another direction in my research is to develop non-invasive evaluation methods for cosmetheutics (anti-aging/whitening/hydration).
This technique is expected to provide criteria in screening raw materials and in the formulation of cosmetheutical products.
My interest in cosmetheutics came from the experiences in a cosmetic company (Amorepacific Co., South Korea)
for more than 7 years, when I had managed in the development of cosmetic products and raw materials as a senior researcher.
Recent Publications
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Yoo B, Pagel MD. An Overview of Responsive MRI Contrast Agents for Molecular Imaging. (Frontiers in Bioscience 2008, 13, 1733-1752). |
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Yoo B, Raam MS, Rosenblum RM. and Pagel MD. Enzyme-responsive PARACEST MRI contrast agents: A new biomedical imaging approach to study the protein degradome. (Contrast Media & Molecular Imaging 2007, 2(4), 189-198. |
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Yoo B, Pagel MD. Peptidyl Molecular Imaging Contrast Agents Using a New Solid Phase Peptide Synthesis Approach. Bioconjugate Chem. 2007, 18, 903-911. |
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Yoo B, Pagel MD. A PARACEST MRI Contrast Agent to Detect Enzyme Activity. J. Am. Chem. Soc. 2006, 128(43), 14032-14033. |
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Yoo B, Pagel MD. A facile synthesis of alpha-amino-DOTA as a versatile molecular imaging probe. Tetrahedron Letters, 2006; 47:7327-7330. |
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