Yuguo Li, Ph.D. Research Associate Biomedical Engineering Office: Room 4956, Arizona Cancer Center Phone: (520)-626-0194 Fax: (520)-626-0395 Email: lyg@u.arizona.edu Mail Address: Room 4956 Arizona Cancer Center 1515 North Campbell Ave. Tucson, AZ 85724
Selected links: • Contrast Agent Molecular Engineering Lab • Biomedical Engineering Program • Arizona Cancer Center • Arizona Research Labs • Institute for Collaborative BioResearch (BIO5) • Advanced Research Institute for Biomedical Imaging (ARIBI) • Biomedical Magnetic Resonance Facility • The University of Arizona

Research Summary

I am interested in the pharmacokinetics of polymeric drug delivery vehicles and controlled release rates of drugs from drug delivery vehicles by using the MRI contrast ag ents. Lanthanide chelates will be conjugated to polymeric systems to measure the rate of tumor accumulation. In addition, "smart" lanthanide chelates will be incorporated into the drug-polymer covalent linker, which can be detected via CEST MRI only after the drug is detached from the polymeric system. CEST MRI methods will be developed to monitor both types of lant hanide chelates to independently monitor the rate of tumor accumulation and the rate of drug release.

Recent Publications