CAMEL Images
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CAMEL Research Group, December 2008
Vipul "Six-Gun" Sheth
Byunghee "Maverick" Yoo
Julio Cardenas, a.k.a., The Mayor
Briana "Quickdraw" Bermudez
Marty "Whip" Pagel
Yuguo "Ranger" Li
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Bruker Biospec 7T MRI scanner
Byunghee Yoo
Yuguo Li
Vipul Sheth
Julio Cardenas
Marty Pagel
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CAMEL Chemistry Laboratory
Arizona Cancer Center
University of Arizona
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Yb-DO3A-oAA PARACEST agent
This contrast agent has been used to detect nitric oxide
and to measure pH in tumors
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PARACEST spectra (A) and MR parametric map (B) of DEVD-(Tm-DOTA) amide before and after addition of caspase-3.
The deconvoluted
PARACEST spectrum of the product after reaction, showing a PARACEST
effect at +8 ppm, is also shown.
The parametric map shows a 14.5% decrease
in water MR signal before the enzymatic reaction, and no significant change
in water MR signal after reaction.
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CAMEL Research Group, Summer 2008
Julio Cardenas
Vipul Sheth
Aswin Sundaram
Yuguo Li
Byunghee Yoo
Marty Pagel
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Measurement of Tumor pH with PARACEST MRI
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Dynamic Contrast Enhancement MRI
DCE-MRI was used to measure changes in tumor vascular
permeability before and after administering an
anti-angiogenic chemotherapy.
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Vipul Sheth Presents a Poster
at the Arizona Health Sciences Center,
University of Arizona
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MR images and Histopathology
show infectiona nd inflammation of a mouse model
of Cystic Fibrosis after innoculation with P. aeruginosa
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CAMEL Research Group, Summer 2007
Marty Pagel
Byunghee Yoo
Guanshu Liu
Meser Ali
Vipul Sheth
Athena Chen
Yuguo Li
Case Western Reserve University
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Byunghee and Guanshu graduate May 2008
Guanshu Liu
Marty Pagel
Byunghee Yoo
Case Western Reserve University
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Bruker Biospec 7T MRI scanner
and Marty Pagel,
Biological Magnetic Resonance Facility
Photo taken by Sarah Jacoby
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