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What do we do?

We study gene networks that control the proliferation and death of cancer cells. Currently, one particular focus is on the Rb-E2F "bistable switch" network that controls the balance between cellular quiescence and proliferation. 

 

 

What is the goal of our research? 

We aim to better understand control mechanisms underlying various cell-fate decisions, and their connections to cancer development and aging, as well as to potential therapeutic strategies.

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Welcome to the Yao Systems Biology Lab at UofA

What is our approach?

We use an integrated computational and experimental approach. Specifically, we work with our collaborators and combine single-cell and large-scale measurements, together with mathematical, statistical, and natural language modeling, to create an integrated platform that holds great promise in dissecting complex and heterogeneous biological systems like cancer.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Cancer cells make aberrant cell-fate decisions: they grow when normal cells would not; they refuse to die when normal cells do given same conditions. What are the biological "switches" underlying the aberrant behaviors of cancer cells?
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