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What do we do?

We study gene networks that control the life and death of cancer cells. Currently, our particular focus is on the Rb-E2F gene network switch that controls the balance between cell proliferation and quiescence.

 

What is the goal of our research? 

We aim to better understand control mechanisms underlying various cell-fate decisions, and their connections to cancer development and aging, as well as to potential therapeutic strategies.

 

What is our approach?

We use an integrated computational and experimental approach. Specifically, we work with our collaborators and combine single-cell and large-scale measurements, together with mathematical and statistical modeling, to dissect complex and heterogeneous biological systems like cancer.

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Welcome to the Yao Systems Biology Lab at UofA
Cancer cells make aberrant cell-fate decisions: they grow when normal cells would not; they refuse to die when normal cells do given same conditions. What are the biological "switches" underlying the aberrant behaviors of cancer cells?
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